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Article

Tumor necrosis factor-alpha -308G>A allelic variant modulates iron accumulation in patients with hereditary hemochromatosis.

Clinical chemistry - 1 Aug 2006

Krayenbuehl Pierre-Alexandre, Maly Friedrich E, Hersberger Martin, Wiesli Peter, Himmelmann Andreas, Eid Karim, Greminger Peter, Vetter Wilhelm, Schulthess Georg

Abstract excerpt

BACKGROUND: In vitro and animal studies suggest that tumor necrosis factor alpha (TNF-alpha) modulates intestinal iron transport. We hypothesized that the effect of TNF-alpha might be particularly relevant if iron absorption is not effectively controlled by the HFE gene. METHODS: In patients with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16793930
DOI: 10.1373/clinchem.2005.065417

Genes

TNF
HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16793930-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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