Article
Cytokine and Gene Expression Profiling in Patients with HFE-Associated Hereditary Hemochromatosis according to Genetic Profile.
Acta haematologica - 1 Jan 2021
Grønlien Heidi Kristine, Christoffersen Trine Eker, Nystrand Camilla Furlund, Garabet Lamya, Syvertsen Terje, Moe Morten K, Olstad Ole Kristoffer, Jonassen Christine Monceyron
Abstract excerpt
BACKGROUND: Hemochromatosis gene (HFE)-associated hereditary hemochromatosis (HH) is characterized by downregulation of hepcidin synthesis, leading to increased intestinal iron absorption. OBJECTIVES: The objectives were to characterize and elucidate a possible association between gene expression profile, hepcidin levels, disease severity, and markers of inflammation in HFE-associated HH patients. METHODS:...
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