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Article

Toll-like receptor 4 gene polymorphism modulates phenotypic expression in patients with hereditary hemochromatosis.

European journal of gastroenterology & hepatology - 1 Jul 2010

Krayenbuehl Pierre-Alexandre, Hersberger Martin, Truninger Kaspar, Müllhaupt Beat, Maly Friedrich E, Bargetzi Mario, Schulthess Georg

Abstract excerpt

BACKGROUND: Clinical penetrance of hereditary hemochromatosis is highly variable. We hypothesized that it might be modified by factors involved in the cellular immune response, such as toll-like receptors (TLRs) or nucleotide oligomerization domain proteins (NODs). METHODS: Clinical expression of hemochromatosis was assessed as a function of TLR4, TLR9, and NOD2 polymorphisms in 99 homozygous carriers of the HFE...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19809335
DOI: 10.1097/MEG.0b013e3283322067

Genes

TLR4
HFE
NOD2
TLR9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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