Article
A study on the TNF-alpha system in Caucasian Spanish patients with alcoholic liver disease.
Drug and alcohol dependence - 1 Jan 2008
Auguet Teresa, Vidal Francesc, López-Dupla Miguel, Broch Montserrat, Gutiérrez Cristina, Olona Montserrat, Oltra Carmina, Aguilar Carmen, González Eva, Quer Joan-Carles, Sirvent Joan-Josep, Richart Cristóbal
Abstract excerpt
BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is thought to be a critical driving force of inflammatory damage in alcoholic liver disease (ALD). We aimed to establish whether there is a correlation between plasma levels of the soluble TNF-alpha receptors 1 and 2 (sTNFR1 and sTNFR2) and the severity of liver damage in patients with ALD. We also aimed to elucidate whether functionally active polymorphisms in...
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