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Article

Role of the 14-3-3 C-terminal loop in ligand interaction.

Proteins - 15 Nov 2002

Truong Amy B, Masters Shane C, Yang Hongzhu, Fu Haian

Abstract excerpt

14-3-3 proteins are a family of conserved dimeric molecules that interact with a broad range of target proteins, most of which contain phosphoserine/threonine. The amphipathic groove of 14-3-3 is the main structural feature involved in mediating its associations. We have studied another domain of 14-3-3, the C-terminal loop, to determine what role it plays in ligand interaction. A truncated form of 14-3-3zeta...

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Identifiers

PMID: 12360521
DOI: 10.1002/prot.10210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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