Article
Characterization of functional roles of DRY motif in the 2nd intracellular loop of dopamine D2 and D3 receptors.
Archives of pharmacal research - 1 Apr 2008
Kim Ju-Heon, Cho Eun-Young, Min Chengchun, Park Jae H, Kim Kyeong-Man
Abstract excerpt
Dopamine D(2)R and D(3)R (D(2)R, D(3)R) show very high sequence homology and employ virtually identical signaling pathways even though D(2)R is 2 approximately 5 times more active. Among the structural motifs identified, a triplet sequence, Asp-Arg-Tyr (DRY motif), plays critical roles in the determination of receptor conformations for signaling and intracellular trafficking of G protein-coupled receptors by...
Topics
- Amino Acid Motifs
- Apomorphine
- Arginine
- Aspartic Acid
- Cell Line
- Cell Membrane
- Cyclic AMP
- Dopamine Agonists
- Dopamine Antagonists
- Dose-Response Relationship, Drug
- Humans
- Mutation
- Protein Conformation
- Protein Structure, Tertiary