Article
Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis.
Science (New York, N.Y.) - 9 Apr 2004
Han Xue, Wang Chih-Tien, Bai Jihong, Chapman Edwin R, Jackson Meyer B
Abstract excerpt
The fusion pore of regulated exocytosis is a channel that connects and spans the vesicle and plasma membranes. The molecular composition of this important intermediate structure of exocytosis is unknown. Here, we found that mutations of some residues within the transmembrane segment of syntaxin (Syx), a plasma membrane protein essential for exocytosis, altered neurotransmitter flux through fusion pores and...
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