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Article

Syntaxin 1A modulates the voltage-gated L-type calcium channel (Ca(v)1.2) in a cooperative manner.

The Journal of biological chemistry - 1 Aug 2003

Arien Hadar, Wiser Ofer, Arkin Isaiah T, Leonov Hadas, Atlas Daphne

Abstract excerpt

Syntaxin 1A (Sx1A) modifies the activity of voltage-gated Ca2+ channels acting via the cytosolic and the two vicinal cysteines (271 and 272) at the transmembrane domain. Here we show that Sx1A modulates the Lc-type Ca2+ channel, Cav1.2, in a cooperative manner, and we explore whether channel clustering or the Sx1A homodimer is responsible for this activity. Sx1A formed homodimers but, when mutated at the two...

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PMID: 12721298
DOI: 10.1074/jbc.M301401200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Syntaxin 1A modulates the voltage-gated L-type calcium channel (Ca(v)1.2) in a cooperative manner.PMID 12721298Read ↗

The transmembrane domain of syntaxin 1A negatively regulates voltage-sensitive Ca(2+) channels.Semantic proximity Read ↗

Intra-membrane signaling between the voltage-gated Ca2+-channel and cysteine residues of syntaxin 1A coordinates synchronous release.Semantic proximity Read ↗

Thiol dependent intramolecular locking of Orai1 channels.Semantic proximity Read ↗

Syntaxin 1A regulation of weakly inactivating N-type Ca2+ channels.Semantic proximity Read ↗

Functional impact of syntaxin on gating of N-type and Q-type calcium channels.Semantic proximity Read ↗

Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel α(2)δ-1 auxiliary subunit.Semantic proximity Read ↗

The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).Semantic proximity Read ↗

Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions.Semantic proximity Read ↗

Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits.Semantic proximity Read ↗

Molecular determinants of syntaxin 1 modulation of N-type calcium channels.Semantic proximity Read ↗

Role of H(abc) domain in membrane trafficking and targeting of syntaxin 1A.Semantic proximity Read ↗

The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions.Semantic proximity Read ↗

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