Article
Contribution of germline MLH1 and MSH2 mutations to lobular carcinoma in situ of the breast.
Cancer letters - 26 Jun 2001
Stone J G, Coleman G, Gusterson B, Marossy A, Lakhani S R, Ward A, Nash A, McKinna A, A'Hern R, Stratton M R, Houlston R S
Abstract excerpt
Lobular carcinoma in situ (LCIS) is an unusual histological pattern of non-invasive neoplastic disease of the breast occurring predominantly in women aged between 40 and 50 years. LCIS is frequently multicentric and bilateral suggesting a genetic basis to the disease. The high frequency of microsatellite instability in lobular breast cancers, coupled with increased risk of breast cancer associated with germline...
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