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Article

Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions.

Breast cancer research : BCR - 9 Jul 2012

Andrade Victor P, Ostrovnaya Irina, Seshan Venkatraman E, Morrogh Mary, Giri Dilip, Olvera Narciso, De Brot Marina, Morrow Monica, Begg Colin B, King Tari A

Abstract excerpt

INTRODUCTION: Lobular carcinoma in situ (LCIS) has been accepted as a marker of risk for the development of invasive breast cancer, yet modern models of breast carcinogenesis include LCIS as a precursor of low-grade carcinomas. We provide evidence favoring a clonal origin for LCIS and synchronous estrogen receptor-positive malignant lesions of the ductal and lobular phenotype. METHODS: Patients with prior LCIS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22776144
DOI: 10.1186/bcr3222
PMCID: PMC3680923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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