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Article

Is MSH2 a breast cancer susceptibility gene?

Familial cancer - 1 Jan 2008

Wong Ee Ming, Tesoriero Andrea A, Pupo Gulietta M, McCredie Margaret R E, Giles Graham G, Hopper John L, Mann Graham J, Goldgar David E, Southey Melissa C

Abstract excerpt

Mutations in the DNA mismatch repair gene MSH2 lead to increased replication error and microsatellite instability and account for a substantial proportion of hereditary non-polyposis colorectal cancer (Lynch syndrome). A recent international collaborative genome-wide linkage scan (GWS) for breast cancer susceptibility loci found some evidence for there being a breast cancer susceptibility gene in a genomic region...

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Source

Identifiers

PMID: 17922223
DOI: 10.1007/s10689-007-9162-8

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Is MSH2 a breast cancer susceptibility gene?PMID 17922223Read ↗

Breast cancer in an MSH2 gene mutation carrier.Semantic proximity Read ↗

Origins and prevalence of the American Founder Mutation of MSH2.Semantic proximity Read ↗

Frequency and variability of genomic rearrangements on MSH2 in Spanish Lynch Syndrome families.Semantic proximity Read ↗

Identification and characterization of genomic rearrangements ofMSH2 andMLH1 in Lynch syndrome (HNPCC) by novel techniquesSemantic proximity Read ↗

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.Semantic proximity Read ↗

Characterization of new founder Alu-mediated rearrangements in MSH2 gene associated with a Lynch syndrome phenotype.Semantic proximity Read ↗

MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1.Semantic proximity Read ↗

Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approachSemantic proximity Read ↗

Familial T-cell non-Hodgkin lymphoma caused by biallelic MSH2 mutations.Semantic proximity Read ↗

Contribution of germline MLH1 and MSH2 mutations to lobular carcinoma in situ of the breast.Semantic proximity Read ↗

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