Article
Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships.
Molecular oncology - 1 Feb 2016
Sakr Rita A, Schizas Michail, Carniello Jose V Scarpa, Ng Charlotte K Y, Piscuoglio Salvatore, Giri Dilip, Andrade Victor P, De Brot Marina, Lim Raymond S, Towers Russell, Weigelt Britta, Reis-Filho Jorge S, King Tari A
Abstract excerpt
PURPOSE: Lobular carcinoma in situ (LCIS) has been proposed as a non-obligate precursor of invasive lobular carcinoma (ILC). Here we sought to define the repertoire of somatic genetic alterations in pure LCIS and in synchronous LCIS and ILC using targeted massively parallel sequencing. METHODS: DNA samples extracted from microdissected LCIS, ILC and matched normal breast tissue or peripheral blood from 30...
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