Lobular Carcinomas In Situ Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma.

doi:10.1158/1078-0432.CCR-18-1103

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Article

Lobular Carcinomas In Situ Display Intralesion Genetic Heterogeneity and Clonal Evolution in the Progression to Invasive Lobular Carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2019

Lee Ju Youn, Schizas Michail, Geyer Felipe C, Selenica Pier, Piscuoglio Salvatore, Sakr Rita A, Ng Charlotte K Y, Carniello Jose V Scarpa, Towers Russell, Giri Dilip D, de Andrade Victor P, Papanastasiou Anastasios D, Viale Agnes, Harris Reuben S, Solit David B, Weigelt Britta, Reis-Filho Jorge S, King Tari A

Abstract excerpt

PURPOSE: Lobular carcinoma in situ (LCIS) is a preinvasive lesion of the breast. We sought to define its genomic landscape, whether intralesion genetic heterogeneity is present in LCIS, and the clonal relatedness between LCIS and invasive breast cancers.Experimental Design: We reanalyzed whole-exome sequencing (WES) data and performed a targeted amplicon sequencing validation of mutations identified in 43 LCIS...

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Identifiers

PMID: 30185420
DOI: 10.1158/1078-0432.CCR-18-1103
PMCID: PMC6726436

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