Article
Clonal relationships between lobular carcinoma in situ and other breast malignancies.
Breast cancer research : BCR - 23 Jun 2016
Begg Colin B, Ostrovnaya Irina, Carniello Jose V Scarpa, Sakr Rita A, Giri Dilip, Towers Russell, Schizas Michail, De Brot Marina, Andrade Victor P, Mauguen Audrey, Seshan Venkatraman E, King Tari A
Abstract excerpt
BACKGROUND: Recent evidence suggests that lobular carcinoma in situ (LCIS) can be a clonal precursor of invasive breast cancers of both the ductal and lobular phenotypes. We sought to confirm these findings with an extensive study of fresh frozen breast specimens from women undergoing mastectomy. METHODS: Patients with a history of LCIS presenting for therapeutic mastectomy were identified prospectively. Frozen...
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