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Article

PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression.

Breast cancer research : BCR - 17 Jan 2017

Shah Vandna, Nowinski Salpie, Levi Dina, Shinomiya Irek, Kebaier Ep Chaabouni Narda, Gillett Cheryl, Grigoriadis Anita, Graham Trevor A, Roylance Rebecca, Simpson Michael A, Pinder Sarah E, Sawyer Elinor J

Abstract excerpt

BACKGROUND: Lobular carcinoma in situ (LCIS) is a non-invasive breast lesion that is typically found incidentally on biopsy and is often associated with invasive lobular carcinoma (ILC). LCIS is considered by some to be a risk factor for future breast cancer rather than a true precursor lesion. The aim of this study was to identify genetic changes that could be used as biomarkers of progression of LCIS to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 28095868
DOI: 10.1186/s13058-016-0789-y
PMCID: PMC5240238

Genes

CCND1
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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