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Article

Hybrid HIV/MSCV LTR Enhances Transgene Expression of Lentiviral Vectors in Human CD34<sup>+</sup>Hematopoietic Cells

1 May 2001

Abstract excerpt

HIV-based lentiviral vectors can transduce nondividing cells, an important advantage over murine leukemia virus (MLV)-based vectors when transducing slowly dividing hematopoietic stem cells. However, we find that in human CD34(+) hematopoietic cells, the HIV-based vectors with an internal cytomegalovirus (CMV) promoter express transgenes 100- to 1,000-fold less than the MLV-based retroviral vector murine stem...

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Identifiers

PMID: 11359949
DOI: 10.1634/stemcells.19-3-236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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