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Efficient Lentiviral Transduction and Improved Engraftment of Human Bone Marrow Mesenchymal Cells

10 Dec 2005

Abstract excerpt

Human bone marrow (BM) mesenchymal stem/progenitor cells are potentially attractive targets for ex vivo gene therapy. The potential of lentiviral vectors for transducing BM mesenchymal cells was examined using a self-inactivating vector that expressed the green fluorescent protein (GFP) from an internal cytomegalovirus (CMV) promoter. This vector was compared with oncoretroviral vectors expressing GFP from the...

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PMID: 16339997
DOI: 10.1634/stemcells.2003-0106

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