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Lentiviral Vectors for Sustained Transgene Expression in Human Bone Marrow–Derived Stromal Cells

1 May 2002

Abstract excerpt

Bone marrow-derived mesenchymal stromal cells (MSCs) have attracted attention as potential platforms for the systemic delivery of therapeutic proteins in vivo following gene transfer using oncogenic retroviruses. However, the major limitations of this strategy include low levels of gene transfer and a general lack of long-term transgene expression. We have investigated the expression of several transgenes in MSCs...

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PMID: 11991746
DOI: 10.1006/mthe.2002.0585

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