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Stable transduction of quiescent CD34 <sup>+</sup> CD38 <sup>−</sup> human hematopoietic cells by HIV-1-based lentiviral vectors

16 Mar 1999

Abstract excerpt

We compared the efficiency of transduction by an HIV-1-based lentiviral vector to that by a Moloney murine leukemia virus (MLV) retroviral vector, using stringent in vitro assays of primitive, quiescent human hematopoietic progenitor cells. Each construct contained the enhanced green fluorescent protein (GFP) as a reporter gene. The lentiviral vector, but not the MLV vector, expressed GFP in nondivided CD34(+)...

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PMID: 10077624
DOI: 10.1073/pnas.96.6.2988

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