Article

Transcriptional targeting of lentiviral vectors to the erythroblastic progeny of hematopoietic stem cells

2003-01-01

Abstract excerpt

Correction of blood genetic disorders requires permanent gene transfer into self renewing, hematopoietic stem cells (HSC), and regulation of transgene expression in specific cell lineages. HIV-derived lentiviral vectors are very effective in transducing rare, non-dividing stem cell populations without altering their long-term repopulation and differentiation capacity. We developed a strategy for transcriptional ta...

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Literature Corpus work: 222c5a3b-de41-5137-8aeb-c12b58c5e783
DOI: 10.21954/ou.ro.0000d615

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