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Article

Lentiviral Vectors for Enhanced Gene Expression in Human Hematopoietic Cells

1 Nov 2000

Abstract excerpt

Accumulated data indicate that current generation lentiviral vectors, which generally utilize an internal human cytomegalovirus (CMV) immediate early region enhancer-promoter to transcribe the gene of interest, are not yet optimized for efficient expression in human hematopoietic stem/progenitor cells (HSPCs). As a first step toward this goal, we constructed self-inactivating derivatives of the HIV-1-based...

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PMID: 11082319
DOI: 10.1006/mthe.2000.0190

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