Article
HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998
Uchida N, Sutton R E, Friera A M, He D, Reitsma M J, Chang W C, Veres G, Scollay R, Weissman I L
Abstract excerpt
Recent studies have opened the possibility that quiescent, G0/G1 hematopoietic stem cells (HSC) can be gene transduced; lentiviruses (such as HIV type 1, HIV) encode proteins that permit transport of the viral genome into the nucleus of nondividing cells. We and others have recently demonstrated efficient transduction by using an HIV-1-based vector gene delivery system into various human cell types including...
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