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Optimized Lentiviral Transduction of Mouse Bone Marrow-Derived Mesenchymal Stem Cells

1 Jun 2008

Abstract excerpt

Mesenchymal stem cells (MSCs) have attracted much attention as potential platforms for transgene delivery and cell-based therapy for human disease. MSCs have the capability to self-renew and retain multipotency after extensive expansion in vitro, making them attractive targets for ex vivo modification and autologous transplantation. Viral vectors, including lentiviral vectors, provide an efficient means for...

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PMID: 18513160
DOI: 10.1089/scd.2007.0194

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