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Article

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

30 Jun 2017

Abstract excerpt

Abstract Clinical application of lentiviral vector (LV)‐based hematopoietic stem and progenitor cells (HSPC) gene therapy is rapidly becoming a reality. Nevertheless, LV‐mediated signaling and its potential functional consequences on HSPC biology remain poorly understood. We unravel here a remarkably limited impact of LV on the HSPC transcriptional landscape. LV escaped innate immune sensing that instead led to...

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PMID: 28667090
DOI: 10.15252/emmm.201707922

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