Article

POT-3 preferentially binds the terminal DNA-repeat on the telomeric G-overhang

2022-07-02

Abstract excerpt

Eukaryotic chromosomes typically end in 3’ telomeric overhangs. The safeguarding of telomeric single-stranded DNA overhangs is carried out by factors related to the Protection of Telomeres 1 (POT1) protein in humans. Of the three POT1-like proteins in C. elegans , POT-3 was the only member thought to not play a role at telomeres. Here, we provide evidence that POT-3 is a bona fide telomere-binding protein. Using...

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Literature Corpus work: 64f9885c-d580-5488-9da2-71614996c3e6
DOI: 10.1101/2022.07.01.497317

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