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Article

Establishment of variant PC12 subclones deficient in stimulation-secretion coupling.

Biochimica et biophysica acta - 15 Jan 2001

Shoji-Kasai Y, Morishima M, Kuwahara R, Kondo S, Itakura M, Takahashi M

Abstract excerpt

Clonal rat pheochromocytoma (PC12) cells have been widely used to study the molecular mechanism of exocytosis. We have isolated variant PC12 subclones with deficiencies in stimulation-secretion coupling, by a single cell recloning, and investigated the defects. PC12-1G2 hardly released dopamine following high-K(+)-induced depolarization, but normal release was evoked by the Ca(2+)-ionophore, ionomycin. Fura-2...

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Identifiers

PMID: 11341965
DOI: 10.1016/s0167-4889(00)00103-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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