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Article

Development of the hypersecretory phenotype in the population of adrenal chromaffin cells from prehypertensive SHRs.

Pflugers Archiv : European journal of physiology - 1 Nov 2021

Peña Del Castillo Johanna Guadalupe, Segura-Chama Pedro, Rincón-Heredia Ruth, Millán-Aldaco Diana, Giménez-Molina Yolanda, Villanueva José, Gutiérrez Luis Miguel, Hernández-Cruz Arturo

Abstract excerpt

The hypersecretory phenotype of adrenal chromaffin cells (CCs) from early spontaneously hypertensive rats (SHRs) mainly results from enhanced Ca2+-induced Ca2+-release (CICR). A key question is if these abnormalities can be traced to the prehypertensive stage. Spontaneous and stimulus-induced catecholamine exocytosis, intracellular Ca2+ signals, and dense-core granule size and density were examined in CCs from...

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PMID: 34510285
DOI: 10.1007/s00424-021-02614-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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