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Article

Role of secretory carrier membrane protein SCAMP2 in granule exocytosis.

Molecular biology of the cell - 1 Dec 2002

Liu Lixia, Guo Zhenheng, Tieu Quyen, Castle Anna, Castle David

Abstract excerpt

In secretory carrier membrane proteins (SCAMPs), the most conserved structural segment is between transmembrane spans 2 and 3, facing the cytosol. A synthetic peptide, CWYRPIYKAFR (E peptide), from this segment of SCAMP2 potently inhibits exocytosis in permeabilized neuroendocrine (PC12) cells. E peptide blocked discharge of (35)S-labeled secretogranin with the same structural selectivity and potency as observed...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12475951
DOI: 10.1091/mbc.e02-03-0136
PMCID: PMC138632

Genes

SCAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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