Article
Dense-core granules: a specific hallmark of the neuronal/neurosecretory cell phenotype.
Journal of cell science - 15 Feb 2004
Malosio Maria Luisa, Giordano Tiziana, Laslop Andrea, Meldolesi Jacopo
Abstract excerpt
Expression of dense-core granules, a typical exocytic organelle, is widely believed to be controlled by coordinate gene expression mechanisms specific to neurones and neurosecretory cells. Recent studies in PC12 cells, however, have suggested the number of granules/cells depends on the levels of only one of their cargo proteins, chromogranin A, regulating the metabolism of the other proteins, and thus the...
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