Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis.

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Article

Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Nov 2003

Khvotchev Mikhail V, Ren Mindong, Takamori Shigeo, Jahn Reinhard, Südhof Thomas C

Abstract excerpt

Using PC12 cells that express transfected human growth hormone (hGH) as a secreted reporter protein, we have searched for Rab proteins that function in exocytosis. Among the Rab proteins tested, we found that besides the previously described Rab3 proteins, only members of the Rab11 family (Rab11a, 11b, and 25) impaired Ca2+-induced exocytosis. Rab11b, which is enriched in brain, had the strongest effect....

Topics

Animals
Calcium
Cell Fractionation
Cell Line
Exocytosis
Genes, Reporter
Green Fluorescent Proteins
Guanosine Diphosphate
Guanosine Triphosphate
Human Growth Hormone
Humans
Kidney
Luminescent Proteins
Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 14627637
PMCID: PMC6740915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons

PC12 Cells

Potassium

Rats