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Article

A common single nucleotide polymorphism alters the synthesis and secretion of neuropeptide Y.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 31 Dec 2008

Mitchell Gregory C, Wang Qian, Ramamoorthy Prabhu, Whim Matthew D

Abstract excerpt

A single nucleotide polymorphism (SNP) in the neuropeptide Y gene has been associated with elevated serum lipid levels and cardiovascular disease. The polymorphism (T1128C) changes the seventh amino acid in the prohormone from leucine to proline. It has been speculated this alters neuropeptide Y (NPY) synthesis, trafficking, or secretion. We tested this hypothesis by expressing the mutant and wild-type...

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Identifiers

PMID: 19118176
DOI: 10.1523/JNEUROSCI.0343-08.2008
PMCID: PMC2664626

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NPY

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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