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Article

A role for the transcriptional repressor REST in maintaining the phenotype of neurosecretory-deficient PC12 cells.

Journal of neurochemistry - 1 Dec 2006

Pance Alena, Livesey Frederick J, Jackson Antony P

Abstract excerpt

The rat PC12 variant cell line, A35C, lacks regulated secretory organelles due to a selective transcriptional block. Hence, A35C may provide clues about the mechanisms that underlie control of neurosecretion. We used mRNA microarray profiling to examine gene expression in A35C. Genes for regulated secretory proteins were down-regulated, while other membrane trafficking pathways were unaffected. A subset of genes...

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Source

Identifiers

PMID: 17064356
DOI: 10.1111/j.1471-4159.2006.04190.x

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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