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Article

Spermine supports catalysis of hairpin ribozyme variants to differing extents.

Biochemical and biophysical research communications - 11 May 2001

Welz R, Schmidt C, Müller S

Abstract excerpt

Because of the ability to cleave RNA substrates in trans, the hairpin ribozyme has great potential for therapeutic application. Activity of a three-stranded version of the minimal truncated form is enhanced by the presence of the polyamine spermine. Since spermine is the most abundant polyamine in eucariots, improved prospects for the hairpin ribozyme as therapeutic agent were predicted. We have found that not...

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Identifiers

PMID: 11341774
DOI: 10.1006/bbrc.2001.4829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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