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Article

The influence of arm length asymmetry and base substitution on the activity of the 10-23 DNA enzyme.

Antisense & nucleic acid drug development - 1 Oct 2000

Cairns M J, Hopkins T M, Witherington C, Sun L Q

Abstract excerpt

A small oligodeoxyribonucleotide derived from in vitro selection has been shown to be capable of efficient sequence-specific cleavage of RNA at purine-pyrimidine junctions. As the reaction readily takes place under simulated physiologic conditions, this molecule described as the 10-23 general purpose RNA-cleaving DNA enzyme, has potential as a therapeutic agent. To further explore the character of this prototype,...

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Source

Identifiers

PMID: 11079572
DOI: 10.1089/oli.1.2000.10.323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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