Article
Targeted cleavage of RNA molecules by human RNase P using minimized external guide sequences.
Antisense & nucleic acid drug development - 1 Feb 1999
Werner M, Rosa E, Al Emran O, Goldberg A R, George S T
Abstract excerpt
The endoribonuclease RNase P processes tRNA-like structures that are assembled out of two separate strands. In these bimolecular constructs, one of the strands is cleaved by the enzyme, and the other one is called the external guide sequence (EGS). A number of EGS with different mutations and deletions were tested for the ability to induce cleavage with human RNase P. Different domains of the original...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.