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Article

In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2Kb.

Journal of virology - 1 Jun 2001

Puglielli M T, Zajac A J, van der Most R G, Dzuris J L, Sette A, Altman J D, Ahmed R

Abstract excerpt

CD8 T cells drive the protective immune response to lymphocytic choriomeningitis virus (LCMV) infection and are thus a determining force in the selection of viral variants. To examine how escape mutations affect the presentation and recognition of overlapping T-cell epitopes, we isolated an LCMV variant that is not recognized by T-cell receptor (TCR)-transgenic H-2Db-restricted LCMV GP33-41-specific cytotoxic T...

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Share to Antigens, Viral
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Histocompatibility Antigen H-2D

Share to Lymphocytic choriomeningitis virus

Share to Major Histocompatibility Complex

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Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 11333891
DOI: 10.1128/JVI.75.11.5099-5107.2001
PMCID: PMC114915

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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