Article
Lower receptor avidity required for thymic clonal deletion than for effector T-cell function.
Nature - 6 Jun 1991
Pircher H, Rohrer U H, Moskophidis D, Zinkernagel R M, Hengartner H
Abstract excerpt
Clonal deletion in the thymus plays a major part in T-cell tolerance to self antigens. But the mechanism of negative selection, its fine specificity and the threshold of affinity and avidity remains unknown. We have now examined these aspects of negative selection with mice expressing a transgenic T-cell receptor with specificity for lymphocytic choriomeningitis virus (LCMV) glycoprotein in association with the...
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