Article
In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991
Aebischer T, Moskophidis D, Rohrer U H, Zinkernagel R M, Hengartner H
Abstract excerpt
Cytotoxic T lymphocyte (CTL)-mediated cytolysis is induced via the interaction of the specific T-cell antigen receptor and the peptidic viral antigen associated with the major histocompatibility complex class I antigen. Here we demonstrate in vitro that lymphocytic choriomeningitis virus (LCMV) c...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Cell Line, Transformed
- Clone Cells
- Cytotoxicity, Immunologic
- DNA, Viral
- Epitopes
- Genetic Variation
- Lymphocytic choriomeningitis virus
- Macromolecular Substances
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- RNA, Viral
- Receptors, Antigen, T-Cell