Article
In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 1991
Aebischer T, Moskophidis D, Rohrer U H, Zinkernagel R M, Hengartner H
Abstract excerpt
Cytotoxic T lymphocyte (CTL)-mediated cytolysis is induced via the interaction of the specific T-cell antigen receptor and the peptidic viral antigen associated with the major histocompatibility complex class I antigen. Here we demonstrate in vitro that lymphocytic choriomeningitis virus (LCMV) can escape the cytotoxic activity of LCMV-specific cloned CTLs by single amino acid changes within the recognized T-cell...
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