Cytotoxic T lymphocytes (CTL) against a transforming gene product select for transformed cells with point mutations within sequences encoding CTL recognition epitopes.

doi:10.1084/jem.176.2.449

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Article

Cytotoxic T lymphocytes (CTL) against a transforming gene product select for transformed cells with point mutations within sequences encoding CTL recognition epitopes.

The Journal of experimental medicine - 1 Aug 1992

Lill N L, Tevethia M J, Hendrickson W G, Tevethia S S

Abstract excerpt

The 94-kD large tumor (T) antigen specified by simian virus 40 (SV40) is sufficient to induce cell transformation. T antigen contains four H-2Db-restricted cytotoxic T lymphocyte (CTL) recognition epitopes that are targets for CTL clones Y-1, Y-2, Y-3, and Y-5. These epitopes have been mapped to T antigen amino acids 207-215 (site I), 223-231 (sites II and III), and 489-497 (site V), respectively. Antigenic site...

Topics

Amino Acid Sequence
Animals
Antigens, Polyomavirus Transforming
Base Sequence
Cell Line
Clone Cells
DNA
Epitopes
H-2 Antigens
Histocompatibility Antigen H-2D
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Sequence Alignment

T-Lymphocytes, Cytotoxic

Transformation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1380062
DOI: 10.1084/jem.176.2.449
PMCID: PMC2119332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1380062-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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