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Article

p53 Missense Mutations in Microdissected High-Grade Ductal Carcinoma In Situ of the Breast

2 May 2001

Abstract excerpt

BACKGROUND: To understand the role of sporadic mutations in the tumor suppressor gene p53 (also known as TP53) in the pathogenesis of breast cancer, it is important to identify at which histologic stage such mutations first occur. We previously showed that a p53 mutation present in invasive breast cancer was found in all surrounding areas of ductal carcinoma in situ (DCIS) but not in areas of hyperplasia or...

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PMID: 11333292
DOI: 10.1093/jnci/93.9.700

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