Article
Molecular and immunohistochemical analysis of p53 mutations in scrapings and tissue from preinvasive and invasive breast cancer.
Virchows Archiv : an international journal of pathology - 1 Dec 1997
Lisboa B W, Vogtländer S, Gilster T, Riethdorf L, Milde-Langosch K, Löning T
Abstract excerpt
Mutations of the p53 gene appear to be one of the most common abnormalities in human cancer. Although many studies have been published about p53 alterations in breast cancer, data on molecular biological detection of p53 mutations in in situ lesions are still rare, and the implications for breast cancerogenesis are unclear. Tissue samples from 83 patients with different stages of breast cancer and from 13...
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