Article
p53 mutations are confined to the comedo type ductal carcinoma in situ of the breast. Immunohistochemical and sequencing data.
Laboratory investigation; a journal of technical methods and pathology - 1 Jul 1994
O'Malley F P, Vnencak-Jones C L, Dupont W D, Parl F, Manning S, Page D L
Abstract excerpt
BACKGROUND: Mutations in the p53 tumor suppressor gene have been identified in breast and many other carcinomas. It is not clear, however, when these mutations occur during breast carcinogenesis. Overexpression of 53 protein has been reported in some ductal carcinoma in situ (DCIS) lesions. To further study the overexpression of p53 in DCIS of the breast and correlate these findings with changes at the molecular...
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