Article
In microdissected ductal carcinoma in situ, HER-2/neu amplification, but not p53 mutation, is associated with high nuclear grade and comedo histology.
Cancer - 1 Dec 2000
Ho G H, Calvano J E, Bisogna M, Borgen P I, Rosen P P, Tan L K, Van Zee K J
Abstract excerpt
BACKGROUND: HER-2/neu and p53 are two molecular markers that have been the focus of investigation in patients with invasive breast carcinoma. However, most of the published data have relied on immunohistochemical detection of the proteins as a surrogate marker of the underlying genetic alterations, a detection method that often gives variable results due to technical factors. In addition, there are limited data...
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