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Article

Is loss of p53 a driver of ductal carcinoma in situ progression?

British journal of cancer - 1 Nov 2022

Morrissey Rhiannon L, Thompson Alastair M, Lozano Guillermina

Abstract excerpt

Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive carcinoma. Multiple studies have shown that DCIS lesions typically possess a driver mutation associated with cancer development. Mutation in the TP53 tumour suppressor gene is present in 15-30% of pure DCIS lesions and in ~30% of invasive breast cancers. Mutations in TP53 are significantly associated with high-grade DCIS, the most likely form...

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Share to Carcinoma, Ductal, Breast
Share to Carcinoma in Situ
Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 35764786
DOI: 10.1038/s41416-022-01885-5
PMCID: PMC9643347

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