Article
P53 protein accumulation in non-invasive lesions surrounding p53 mutation positive invasive breast cancers.
Breast cancer research and treatment - 1 Jan 2001
Done S J, Arneson C R, Ozçelik H, Redston M, Andrulis I L
Abstract excerpt
p53 mutation is a common event in sporadic breast cancer being found in 15-50% of invasive carcinomas. The purpose of this study was to determine the earliest histologic stage at which p53 mutation could be detected with a widely used anti-p53 antibody (DO7, Novocastra) which recognizes both wild type and mutant forms. p53 expression was assessed immunohistochemically in 12 primary breast carcinomas with known...
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