Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning.

doi:10.1101/gad.191301

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Article

Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning.

Genes & development - 1 May 2001

Nutt S L, Dingwell K S, Holt C E, Amaya E

Abstract excerpt

Signal transduction through the FGF receptor is essential for the specification of the vertebrate body plan. Blocking the FGF pathway in early Xenopus embryos inhibits mesoderm induction and results in truncation of the anterior-posterior axis. The Drosophila gene sprouty encodes an antagonist of FGF signaling, which is transcriptionally induced by the pathway, but whose molecular functions are poorly...

Topics

Amino Acid Sequence
Animals
Body Patterning
Calcium
Embryo, Nonmammalian
Embryonic Induction
Fibroblast Growth Factors
Gastrula
Gene Expression Regulation, Developmental
Mesoderm
Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nerve Tissue Proteins

Phosphorylation

Receptors, Fibroblast Growth Factor

Signal Transduction

Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 11331610
DOI: 10.1101/gad.191301
PMCID: PMC312687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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