Article
Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis.
Mechanisms of development - 1 Apr 2001
Mailleux A A, Tefft D, Ndiaye D, Itoh N, Thiery J P, Warburton D, Bellusci S
Abstract excerpt
Experimental evidence is rapidly emerging that the coupling of positive regulatory signals with the induction of negative feedback modulators is a mechanism of fine regulation in development. Studies in Drosophila and chick have shown that members of the SPROUTY family are inducible negative regulators of growth factors that act through tyrosine kinase receptors. We and others have shown that Fibroblast Growth...
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