Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.

Cell - 23 Jan 1998

Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow M A

Abstract excerpt

Antagonists of several growth factor signaling pathways play important roles in developmental patterning by limiting the range of the cognate inducer. Here, we describe an antagonist of FGF signaling that patterns apical branching of the Drosophila airways. In wild-type embryos, the Branchless FGF induces secondary branching by activating the Breathless FGF receptor near the tips of growing primary branches. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Share to Restriction Mapping

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 9458049
DOI: 10.1016/s0092-8674(00)80919-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.PMID 9458049Read ↗

Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila.Semantic proximity Read ↗

branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching.Semantic proximity Read ↗

Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis.Semantic proximity Read ↗

Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning.Semantic proximity Read ↗

Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting.Semantic proximity Read ↗

Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.Semantic proximity Read ↗

Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.Semantic proximity Read ↗

The bHLH transcription factor, hairy, refines the terminal cell fate in the Drosophila embryonic trachea.Semantic proximity Read ↗

FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation.Semantic proximity Read ↗

Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system.Semantic proximity Read ↗

Identification of FGF-dependent genes in the Drosophila tracheal system.Semantic proximity Read ↗

Interplay of Notch and FGF signaling restricts cell fate and MAPK activation in the Drosophila trachea.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.