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Article

Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps.

Molecular and cellular biology - 1 Jan 2000

O'Reilly A M, Pluskey S, Shoelson S E, Neel B G

Abstract excerpt

In Xenopus ectodermal explants (animal caps), fibroblast growth factor (FGF) evokes two major events: induction of ventrolateral mesodermal tissues and elongation. The Xenopus FGF receptor (XFGFR) and certain downstream components of the XFGFR signal transduction pathway (e.g., members of the Ras/Raf/MEK/mitogen-activated protein kinase [MAPK] cascade) are required for both of these processes. Likewise, activated...

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Identifiers

PMID: 10594032
DOI: 10.1128/MCB.20.1.299-311.2000
PMCID: PMC85085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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