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Article

Lefty antagonism of Squint is essential for normal gastrulation.

Current biology : CB - 23 Dec 2002

Feldman Benjamin, Concha Miguel L, Saúde Leonor, Parsons Michael J, Adams Richard J, Wilson Stephen W, Stemple Derek L

Abstract excerpt

Activities of a variety of signaling proteins that regulate embryogenesis are limited by endogenous antagonists. The zebrafish Nodal-related ligands, Squint and Cyclops, and their antagonists, Lefty1 and Lefty2, belong to the TGFbeta-related protein superfamily, whose members have widespread biological activities. Among other activities, Nodals direct the formation of most mesendoderm. By inducing their own...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12498688
DOI: 10.1016/s0960-9822(02)01361-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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